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NUCALA is indicated as an add-on treatment in adult patients (18 years and above) with severe chronic rhinosinusitis with nasal polyps (CRSwNP) with an inadequate response to intranasal corticosteroids

Size of nasal polyps, Nasal congestion, Need for repeat surgery

Ask your doctor about NUCALA today.

If your nasal polyp symptoms have returned after surgery, find out why they may come back.

See how NUCALA can help treat CRSwNP.

Curious about taking your medication at home? See your options.

Nasal polyps are growths that form in your nasal passages or sinuses.

Nasal polyps are growths that form in your nasal passages or sinuses. Your doctor may refer to your condition as nasal polyps or as chronic rhinosinusitis with nasal polyps (CRSwNP). Nasal polyp symptoms can include nasal congestion, nasal discharge, mucus in the throat, loss of smell, and facial pressure

When you have nasal polyps (CRSwNP), there is typically inflammation in your nasal passages. Eosinophils [ee-uh-sin-uh-fils], a type of white blood cell, play an important role in this inflammatory process. Despite surgical procedures, nasal polyps can come back

Tell your doctor if you've had surgery but your nasal polyp symptoms have come back. Tell your doctor everything you're doing to manage your nasal polyps, and if your symptoms are continuing or getting worse. Talk to your doctor if your nasal polyp symptoms interfere with your daily life - like disrupting your sleep, causing fatigue, or impacting how you feel emotionally.

NUCALA is indicated as an add-on treatment in adult patients (18 years and above) with severe chronic rhinosinusitis with nasal polyps (CRSwNP) with an inadequate response to intranasal corticosteroids

Size of nasal polyps, Nasal congestion, Need for repeat surgery.

After taking NUCALA, people reported improved quality of life,† including nasal symptoms, ear and facial symptoms, fatigue, sleep, and overall emotional impact

NUCALA improved nasal polyp symptoms like nasal blockage, runny nose, post-nasal discharge, and loss of smell

NUCALA reduced the need for steroids

NUCALA is a biologic; it's not a steroid. It's an injection you get every 4 weeks. When NUCALA is added to your current treatment plan, it can help reduce your symptoms of CRSwNP (like nasal congestion, nasal discharge, mucus in the throat, and loss of smell) and helps prevent the need for surgery. NUCALA helps reduce the size of your nasal polyps and the use of steroids*.

Eosinophils are a normal part of your immune system, but in higher numbers, they can cause inflammation6. NUCALA helps reduce eosinophils in the blood, so it treats a source of inflammation3. Inflammation can play a role in CRSwNP.

Your current treatment may not be controlling your symptoms and not addressing an underlying cause of your nasal polyps: eosinophils.

Nasal polyps affect people differently, so it's important to talk to your doctor about all of your symptoms.

NUCALA targets eosinophils, but what exactly does that mean?

Eosinophils [ee-uh-sin-uh-fils] are white blood cells that are a normal part of the body's immune system

When you have CRSwNP there is inflammation in your nasal passages. Eosinophils, a type of white blood cell, generally play an important role in this inflammation. Despite surgical procedures, nasal polyps can come back.

By reducing the number of eosinophils in your blood, Nucala may reduce the size of your nasal polyps and their associated symptoms. Nucala may also be an alternative to surgery. If you are taking oral or injectable steroids, Nucala may also help reduce the need for steroids to control your CRSwNP

NUCALA Mechanism of action in CRSwNP

At the medical centre: If you want to receive your NUCALA injections from your doctor, you can have NUCALA administered at the medical centre.

At home on your time: NUCALA can also be taken at home with the prefilled pen. Your doctor will provide information on how to properly inject at home.

NUCALA pre-filled pen is a 4 weekly injection as an add-on treatment in adult patients (18 years and above) with severe chronic rhinosinusitis with nasal polyps (CRSwNP) with an inadequate response to intranasal corticosteroids1.

Don't like needles? With the NUCALA pre-filled pen, you don't have to see the needle.

After you learn how to properly self-inject from your doctor, you can do it on your own in the comfort of your own home with the NUCALA pre-filled pen.

Once you and your specialist decide that the NUCALA Pre-filled pen is right for you, you will be given information on how to properly inject and how to monitor for allergic reactions. Sometimes, serious allergic reactions, including anaphylaxis, can occur hours or days later.

Instruction for injecting

Pre-filled pen frequently asked questions

Risks and side effects

NUCALA is used as an add-on treatment in adult patients (18 years and above) with severe chronic rhinosinusitis with nasal polyps (CRSwNP) with an inadequate response to intranasal corticosteroids.
NUCALA may reduce the size of your nasal polyps and their associated symptoms. NUCALA may also be an alternative option to surgery. If you are taking systemic steroids, NUCALA may also help reduce the need for steroids to control your CRSwNP

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA (see “What are the ingredients in NUCALA?” below).
It is not known if NUCALA for CRSwNP is well-tolerated and effective in children under 18 years of age.

are taking oral or inhaled corticosteroid medicines. Do not stop taking your corticosteroid medicines unless instructed by your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back

Allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your NUCALA injection. Allergic reactions can sometimes happen hours or days after you get a dose of NUCALA.
Herpes zoster infections that can cause shingles have happened in people who receive NUCALA.

The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and tiredness (fatigue). Mouth/throat pain and joint pain have been reported with CRSwNP.

Active ingredient: mepolizumab.
Inactive ingredients: citric acid monohydrate, EDTA disodium dihydrate, polysorbate 80, sodium phosphate dibasic heptahydrate, and sucrose.

Get information about NUCALA coverage, cost and assistance

NUCALA is not currently funded for CRSwNP in New Zealand. Patients with medical insurance should contact their insurer directly to understand whether NUCALA is covered within existing policies.

NUCALA is fully funded for severe eosinophilic asthma. Special Authority criteria apply. Discuss this with your doctor for further advice.

Curious about how NUCALA can help treat severe eosinophilic asthma?

Resources

Doctor Discussion Guide

Starter Kit